| COURSE | BIOL414 - WHEN BIOCHEMISTRY MEETS EPIGENETICS |
| TYPE OF COURSE | Ellective |
| YEAR | 2nd-4th year undergraduate Biology students |
| SEMESTER | Spring |
| CREDITS | 3 (ECTS=5) |
| DEPARTMENT | Biology, University of Crete |
| LECTURES | Biology Auditorium I, Tuesday 16:00-18:00 |
| COURSE MATERIAL | In Google Classroom (class code: exmrmy4) you can have access to i. textbooks of the course, ii. Powerpoint presentations of the lectures, iii. pdf files of the lecture presentations, iv. previous exams questions & answers, v. Video files of ZOOM lectures, vi. educational videos. |
Download: INFO pptx (INFO pdf)
- Introduction to Epigenetics
- The history of Epigenetics in CSHL Symposia
- Model organisms for the study of Epigenetics
- Definition of Epigenetics
- The basis of the transcription process
- DNA packaging and chromatin architecture
- Modifying chromatin structure
- Nucleosome remodeling complexes
- Chromatin modification
- DNA methylation
Chromatin modifications and their mechanism of Action
- Histones and acetylation regulate transcription
- Acetylation and Deacetylation
- Phosphorylation
- Methylation
- Ubiquitinylation
- Sumoylation
- Open questions in histone modifications
- Histone code
RNAi and Heterochromatin Assembly
- Overview of the RNAi pathway
- Early evidence implicating RNA as an intermediate in TGS
- RNAi and heterochromatin assembly in S.pombe
- Conservation of RNAi-mediated chromatin modifications in animals
- Analysis of Gene-specific DNA Methylation
- Methods for Assessing Genome-wide DNA Methylation
- Epigenetic Technology
- Chromatin Modifications Distinguish Genomic Features and Physical Organization of the Nucleus
- Assessing Epigenetic Information.
- Metabolic regulation of DNA methylation in mammals
- Dietary and metabolic compounds affecting chromatin dynamics/remodeling
Download: Lecture 7 pptx (Lecture 7 pdf)
